The advancement of science relating to all aspects of opioid research primarily by providing an international forum where there can be exchanges of information among interested scientists from different disciplines.
Program
Monday, June 15:
15:00-20:00 Registration
18:00-20:00 Welcome reception
Tuesday, June 16:
8:00-9:00 INRC/CPDD Plenary 1
Nora Volkow - Director, National Institute on Drug Abuse (NIDA)
9:00-10:00 Session 1 (Chair: Fred Nyberg, Uppsala University)
“Addiction to Prescription Opioids”
Thomas Clausen (University of Oslo)
Prescription opioid-abuse and dependence in Scandinavian Countries
Gabriele Fischer (Medical University of Vienna)
Addiction and diversion of prescription opioids in Europe
Pauline Voon (St. Paul's Hospital, Vancouver, CAN)
Nonmedical prescription opioid use in North America
10:00 – 10:15 Break
10:15 – 11:00 Hot Topics – Prescription Opioid Addiction
Naoko Kuzumaki (Toshi University, Tokyo)
Chronic pain and addiction
Paul Bigliardi (1IMB/A*STAR, 8A Biomedical Grove, Singapore)
Clinical manifestations of opioids in skin
TBD
11:00-11:30 Discussion
11:30-13:30 Lunch & Even numbered posters (with CPDD)
13:30-14:45 Founders’ Lecture
Gavril Pasternak (Memorial Sloan-Kettering Cancer Center)
40 years on drugs: It’s all in the telling of the tail
14:45-15:00 Break
15:00-16:00 Session 2 (Chairs: Jay McLaughlin, Torrey Pines Institute for Molecular Studies; Jane Aldrich, University of Florida)
“Advances in Therapeutic Design - Opioid and Sigma Targets”
Chris McCurdy (University of Mississippi)
TBD
Andy Coop (University of Maryland)
UMB425: A Unique Opioid Analgesic with Lower Tolerance
Hank Mosberg (University of Michigan) Development of bifunctional MOR agonist/DOR antagonist peptides: Successes and failures
Jane Aldrich (University of Florida)
TBD
16:00 – 16:30 Hot Topics (TBD, 3 speakers)
16:30 - 17:00 Discussion
Wednesday, June 17:
8:00 - 08:30 INRC Plenary 1 - John Williams (Vollum Institute)
“What is all the confusion about opioid actions on dopamine neurons?”
8:30 – 9:00 Elyssa Margolis (UCSF)
9:00 – 9:30 MOP in the VTA
Kevin D. Wickman (University of Minnesota)
TBD
Adrianne R. Wilson-Poe (Columbia University)
Inflammatory pain dysregulates opioid function in the mesolimbic pathway
9:30 – 9:45 Discussion
9:45 - 10:00 Break
10:00 - 11:45 Session 3 (Chair: Frank Porreca, University of Arizona- Tucson)
“Pain and Reward”
Frank Porreca
TBD
Howard Fields (UCSF)
TBD
Catherine Cahill (UC-Irvine)
TBD
Siri Leknes (Oslo University Hospital)
TBD
11:45 - 12:00 Discussion
12:00 - 14:00 Lunch & Odd numbered posters (with CPDD)
14:00 - 16:00 INRC/CPDD Plenary 2 (Chair: Sandra Comer, Columbia University)
“Novel Strategies for Reducing Opioid Abuse”
Kathy Cunningham (University of Texas Medical Branch, Galveston)
TBD
Marco Pravetoni (University of Minnesota)
TBD
Jermaine Jones (Columbia University)
TBD
Ted Cicero (Washington University, St. Louis)
Epidemiology on the impact of opioid abuse-deterrent medications on opioid abuse in
the community
16:00 - 16:15 Break
16:15 - 17:00 Session 4 (Chair: Robert W. Gereau IV, Washington University-St. Louis)
“Optogenetics in Pain”
Robert W. Gereau IV (Washington University-St. Louis)
Fully-implantable wireless optoelectronic systems for interrogation of spinal and
peripheral pain circuitry
Anthony Pickering (University of Bristol)
Opto- and chemo-genetic activation of brainstem POMC neurones reveals opioid-
mediated analgesic and cardiorespiratory roles
Zhizhong Z. Pan (The University of Texas MD Anderson)
TBD
17:00 - 17:15 Discussion
Thursday, June 18:
8:00-10:00 INRC posters still up
8:00 - 9:00 Session 5 (Chair: Mary Jeanne Kreek, Rockefeller University)
“Vaccines to Prevent Drug Abuse”
Brian Reed (Rockefeller University)
Application of a novel small molecule vaccine platform to oxycodone immunization
Gary Matyas (Walter Reed Army Institute of Research)
Development and Optimization of a Heroin Vaccine
Paul Bremer (Scripps Research Institute)
Design of haptens and conjugate vaccines for heroin addiction
Joel Schlosburg (Scripps Research Institute)
Selectivity, capacity, durability: putting a heroin vaccine through its paces and clearing
the major hurdles towards clinical viability
9:00 – 9:30 Hot Topics - (TBD, 3 speakers)
9:30 – 9:45 Discussion
9:45 – 10:00 Break
10:00 – 12:00 INRC/CPDD Plenary 3 (Chair: Todd W. Vanderah, University of Arizona)
“Cannabinoid Mechanisms and Interventions”
Alexandros Makriyannis (Northeastern University)
TBD
Aron Lichtman (Virginia Commonwealth University)
Inhibition of the 2-AG biosynthetic enzyme diacylglycerol lipase beta: Antinociception
through a cannabinoid receptor independent pathway
Todd W. Vanderah (University of Arizona-Tucson)
TBD
Andrea Hohmann (Indiana University)
The Therapeutic Promise of Nonpsychoactive Cannabinoid Analgesics
12:00 - 13:00 Data Blitz + Lunch (Chair: Susan L. Ingram, Oregon Health and Science University)
13:00 - 14:00 Optional Early Career Event- Mock Study Section (Chair: José Moron-Concepción, Columbia University)
Friday, June 19:
8:00 - 9:15 Session 6 (Chair: Michael M. Morgan, Washington State University-Vancouver; Moderator: Tally M.
Largent-Milnes, University of Arizona)
“Opioid tolerance and Hyperalgesia (real consequences, treatment, mechanisms)”
Michael M. Morgan (Washington State University-Vancouver)
Why are there so many mechanisms of opioid tolerance?
Bradley K. Taylor (University of Kentucky)
TBD
Lori Eidson (Georgia State University)
Role of glia in opioid tolerance
Jürgen Sandkühler (Medical University of Vienna)
CNS mechanisms leading to opioid-induced Hyperalgesia
Dorit Pud (University of Haifa)
Opioids and abnormal pain perception in human
9:15 – 9:45 Discussion
9:45 – 10:00 Break
10:00 - 11:00 Session 7 (Chair: Michael M. Morgan, Washington State University-Vancouver)
“Non-canonical actions of opioids”
Eamonn Kelly (University of Bristol)
GRKs, arrestins and bias at the mu opioid receptor
Lakshmi Devi (Mt. Sinai Hospital)
Regulation of Opioid Receptor Function by Post-endocytic Peptide Processing
Michael Lacagnina (Duke University)
Neuroimmune signaling and opioids: impact of early-life experience on glial function and
addiction-related behaviors
Wendy Walwyn (UCLA)
A role for constitutively active mu opioid receptors in the recovery from chronic pain
11:00 – 11:30 Hot Topics - (TBD, 3 speakers)
11:30 - 11:45 Discussion
12:00 -13:00 Lunch
13:00 – 14:00 Young Investigator Plenary - Gregory Scherrer (Stanford University)
14:00 - 14:15 Break
14:15 - 15:15 Session 9 Young Investigator (Chair: Gregory Scherrer)
Sarah Ross (University of Pittsburgh)
TBD
Steeve Bourane (Salk Institute for Biological Studies)
TBD
15:15 - 15:45 Hot topics- (TBD, 3 speakers)
15:45 - 16:00 Discussion
16:00-17:00 Business Meeting (INRC President, Fred Nyberg)
18:00 - end Closing Banquet