Fluphenazine is an anti-psychotic medication in a group of drugs called phenothiazines. It works by changing the actions of chemicals in your brain
Abstract
Fluphenazine is an anti-psychotic medication in a group of drugs called phenothiazines. It works by changing the actions of chemicals in your brain
[2]
Brand Names
Prolixin,
Permitil,
Dapotum,
Lyogen,
Moditen,
Omca,
Sediten,
Selecten,
Sevinol,
Sinqualone,
Trancin
[2]
Manufacturers
LANNETT CO. INC
PREPAK SYSTEMS
VIBRANTA INC
SANDOZ
TEVA USA
MYLAN
TORRENT PHARMA
QUALITY CARE
PHYSICIANS TC
[1]
History
In April 2005, FDA notified healthcare professionals that patients with dementia-related psychosis treated with atypical antipsychotic drugs are at an increased risk of death. Since issuing that notification, FDA has reviewed additional information that indicates the risk is also associated with conventional antipsychotics. Fluphenazine hydrochloride is not approved for the treatment of patients with dementia-related psychosis
[3]
Uses
Fluphenazine is used to treat psychotic disorders such as schizophrenia.
[2]
Pharmacology
Fluphenazine HCl has activity at all levels of the central nervous system as well as on multiple organ systems. The mechanism whereby its therapeutic action is exerted is unknown.
[4]
Schedule
It is not a controlled substance in the US.
Dosage
The general dosing is: 1-2.5 mg PO qDay; titrate dose to response
Initial 2.5-10 mg/day PO divided q6-8hr
Maintenance: 1-5 mg PO/IM divided q6-8hr
Not to exceed 40 mg/day
Decanoate: 12.5-75 mg (25 mg/mL) IM/SC q2-4week
[5]
Drug Interactions
Contraindicated interactions with:
amiodarone
arsenic trioxide
astemizole
bepridil
cisapride
disopyramide
ibutilide
indapamide
metrizamide
pentamidine
pimozide
procainamide
quinidine
sotalol
terfenadine
Serious interactions with:
amoxapine
apomorphine
bromocriptine
cabergoline
chlorpromazine
clarithromycin
clomipramine
droperidol
epinephrine
fluconazole
fluoxetine
formoterol
gatifloxacin
paroxetine
pergolide
pericyazine
perphenazine
pipotiazine
pramipexole
probucol
venlafaxine
yohimbe
ziprasidone
Significant interactions with:
amisulpride
amitriptyline
amobarbital
amoxapine
darifenacin
dasatinib
desflurane
desipramine
henbane
hexobarbital
homatropine
hydrocodone
hydromorphone
mephentermine
mephobarbital
meprobamate
mesoridazine
morphine
motherwort
moxonidine
nabilone
ziconotide
ziprasidone
zotepine
[6]
Adverse Effects
Akathesia (60%; maybe less with decanoate form)
Dystonia
Dyskinesia
Muscle stiffness
NMS (infrequent but serious)
Parkinsonism
Tardive dyskinesia
Anticholinergic effects
Sedation
Weight gain
Erectile dysfunction
Oligomenorrhea/amenorrhea
[7]
Contraindications
Documented hypersensitivity
Coma, severe hypotension, severe CNS depression, concurrency with large amounts of CNS depressants, subcortical brain damage, poorly controlled seizure disorder, blood dyscrasias, severe cardiovascular disease
Narrow-angle glaucoma
Lactation
[8]
Cautions
Glaucoma, prostatic hypertrophy, stenosing PUD, history of NMS, Parkinson's disease, hypocalcemia, renal/hepatic impairment, patients who have exhibited a severe reaction to insulin or ECT, history of seizures, asthma, respiratory tract infections, cardiovascular disease
Mild leukocytosis, leukopenia, and eosinophilia occasionally occur
Dermatological reactions are common
Watch for urinary retention, blurred vision, dry mouth, and constipation as a result of anticholinergic effects
In case of severe hypotension, use norepinephrine or phenylepinephrine, do NOT use epinephrine or dopamine
May need anticholinergic antiparkinsonian agent to counter EPS
FDA Warning regarding off-label use for dementia in elderly
[8]
Pricing
The pricing varies depending on what form one would like to buy, and the brand.
The 5mg tablet is priced in between $0.16 to $1.66. The prices for 1mg tablet vary from
$0.11 to $0.78. Other dosage may be priced in the range of $0.13 to $1.95
[1]
Referenecs
[1] http://reference.medscape.com/drug/fluphenazine-342973#90
[2] http://www.drugs.com/mtm/lurasidone.html
[3] http://www.drugs.com/pro/fluphenazine-tablets.html
[4] http://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=13947
[5] http://reference.medscape.com/drug/fluphenazine-342973#0
[6] http://reference.medscape.com/drug/fluphenazine-342973#3
[7] http://reference.medscape.com/drug/fluphenazine-342973#4
[8] http://reference.medscape.com/drug/fluphenazine-342973#5
