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Amphetamines were first synthesized in 1887 by the drug company Smith, Kline and French. The amphetamines are indirect-acting sympathomimetic amines and powerful central nervous system stimulants which are used in the therapy of attention deficit disorder, hyperactivity and narcolepsy. Amphetamines also have a potential for abuse and illicit forms of amphetamines constitute some of the most dangerous but widely used drugs of abuse. High doses of amphetamines can be associated with liver injury and distinctive forms of clinically apparent liver injury which has been most commonly associated with methylenedioxymetamphetamine

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